Company list · updated daily

AI-native companies in San Francisco hiring (2026)

The AI-native companies in San Francisco hiring the most right now are Databricks, OpenAI and Anthropic. 21% of the companies listed here have most of their open roles remote. Open roles are read daily from each company’s own careers page.

An AI-native company is built around AI models from its first product: the model is the product or its core, not a feature added later. Companies here are classified from their own product descriptions and hiring, and ranked by how many roles they have open now.

#CompanyHeadquartersOpen rolesRemote
1DatabricksDatabricksDatabricks provides a unified data and AI platform for data management, analytics, data warehousing, governance, business intelligence, applications, and AI agents. The platform enables enterprises to build, tune, deploy, and monitor generative AI models with data lineage, quality, control, and privacy maintained across the entire AI workflow.San Francisco, US83677%
2OpenAIOpenAIOpenAI is an AI research and deployment company. Its main offerings include developing AI technologies with a commitment to safety and alignment with human values.San Francisco, US6896%
3AnthropicAnthropicAnthropic’s flagship product is Claude, a family of large language models and AI assistant products. Anthropic also offers developer offerings like Claude API and Claude Code. Claude assists with tasks such as drafting content, coding, customer support, research, and education.San Francisco, US5289%
4CleraCleraClera is an AI talent agent that matches candidates with startup roles based on their goals, skills, and preferences. It provides personalized introductions, curated job opportunities, and guidance throughout the application and interview process.San Francisco, US26120%
5HarveyHarveyHarvey provides domain-specific AI for legal and professional services. Its products streamline workflows in contract analysis, due diligence, compliance, and litigation.San Francisco, US2555%
6BrexBrexBrex is an intelligent finance platform that combines global corporate cards and banking with spend management, bill pay, and travel software. The platform enables founders and finance teams to accelerate operations, gain real-time visibility, and control spend. Brex uses AI-native automation to eliminate manual expense and accounting tasks for customers.San Francisco, US21222%
7SierraSierraSierra helps businesses build and deploy AI agents that communicate with users across channels such as chat, voice, email, and messaging. The platform is designed to create better, more human customer experiences with AI.San Francisco, US15830%
8Scale AIScale AIYC S16Scale AI provides high-quality data and full-stack technologies that power the world's leading models and enable enterprises and governments to build, deploy, and oversee AI applications. The Scale Generative AI Platform allows customers to build, evaluate, and control advanced AI agents and applications, while the Scale Data Engine provides technology to collect, curate, and annotate high-quality datasets.San Francisco, US15641%
9CursorCursorCursor incorporates multi-file reasoning, repository-wide search, and agentic workflows that can plan and execute refactors or feature additions across many files at once.San Francisco, US12947%
10DecagonDecagonDecagon is a conversational AI platform that enables brands to deploy AI agents for customer support across voice, chat, email, and SMS. Its technology resolves customer inquiries autonomously, and it serves enterprises like Avis Budget Group, Chime, and Oura Health.San Francisco, US1227%
11Horizon3 AIHorizon3 AIHorizon3.ai’s world-class product and research teams are building a highly scalable platform that brings all of these capabilities and more into one place to power an integrated, dynamic, and continuous security approach.San Francisco, US11964%
12MotiveMotiveMotive also offers integrated solutions for spend management and maintenance, enabling businesses to control costs and improve operational efficiency. Motive develops technology that connects and automates physical operations for businesses across various industries. The company provides a platform that combines telematics, fleet management, compliance tools, equipment monitoring, and AI-powered safety solutions.San Francisco, US11992%
13PerplexityPerplexityPerplexity AI is a conversational search engine that uses large language models (LLMs) to provide direct answers to search queries, complete with source citations.San Francisco, US10514%
14LangChainLangChainLangChain’s platform includes LangSmith for observability, evaluation, and deployment, and open source frameworks LangChain, LangGraph, and Deep Agents.San Francisco, US9734%
15BasetenBasetenBaseten provides a platform for training, deploying, and serving artificial intelligence models in production environments. Baseten also offers preconfigured model APIs and deployment options that can run either on its managed cloud service or within a customer's own environment.San Francisco, US8715%
16GongGongGong provides an AI-powered revenue intelligence platform that captures and analyzes customer interactions. The platform delivers insights and workflow automation to revenue teams, including sales, RevOps, customer success, and enablement teams.San Francisco, US8617%
17CognitionCognitionCognition is an applied AI lab building end-to-end software agents. Its flagship product, Devin, is the first AI software engineer that plans, writes, tests, and ships production code autonomously. Cognition also operates Windsurf, an agent-native IDE with its own enterprise customer base.San Francisco, US8313%
18MercorMercorMercor is an AI data company that builds the layer between human expertise and frontier AI models. Mercor Enterprise helps Fortune 500 companies capture how their best people work and translate that expertise into AI agents.San Francisco, US800%
19DeepgramDeepgramYC W16Deepgram provides real-time APIs for speech-to-text, text-to-speech, and voice agents. More than 200,000 developers and 1,300+ organizations build voice offerings powered by Deepgram.San Francisco, US7995%
20Together AITogether AITogether AI provides a cloud platform for developing, training, fine-tuning, and deploying generative AI models. Its services include serverless and dedicated model inference, GPU compute infrastructure, managed storage, code sandboxes, and model customization tools.San Francisco, US7232%
21HappyRobotHappyRobotYC S23HappyRobot’s platform provides AI agents that handle communication, workflow execution, and process automation across enterprise operations.San Francisco, US7130%
22SuperhumanSuperhumanSuperhuman is an AI productivity platform whose products include an AI-powered email app, collaborative workspaces, and a proactive AI assistant.San Francisco, US6141%
23ion designion designION is an AI growth team for ecommerce storefronts that continuously runs agents to find, build, and test ways to increase traffic and conversion. It also offers a design-to-code platform that learns from existing code to write components.San Francisco, US600%
24Higgsfield AIHiggsfield AIHiggsfield AI is an AI-native video reasoning engine that transforms lightweight inputs into cinematic short-form videos within seconds. It offers AI-powered video creation and editing tools, including the Diffuse app, which enables users to create personalized human characters from a single selfie. The platform serves creators, marketing agencies, and filmmakers with a unified creative workflow.San Francisco, US5515%
25HiveHiveHive’s technology is used for content moderation, brand protection, sponsorship measurement, and context-based ad targeting.San Francisco, US540%
26NooksNooksNooks is an applied AI lab building the Agent Workspace for GTM, designing AI agents that operate across the full sales action set.San Francisco, US4831%
27ExaExaExa provides a search API that accepts natural language queries and produces token-efficient results with citations. Exa Agent is a high-compute web agent that synthesizes information from across the web for deep research and enrichment workflows.San Francisco, US470%
28FactoryFactoryThe platform is used by enterprise engineering organizations including MongoDB, EY, Bayer, Zapier, and Clari.San Francisco, US4711%
29BenchlingBenchlingBenchling is the AI platform for biotech R&D. Scientists use Benchling to design experiments, capture structured data, and run AI agents and models directly in their workflows. Over 200,000 scientists around the world trust Benchling to power their most important work, from academic labs to Sanofi, Moderna, and more than half of the world's top 50 biopharma.San Francisco, US4711%
30OverviewOverviewYC W19Overview builds AI-powered quality control systems for manufacturing. Its systems integrate directly into production lines alongside existing PLCs and equipment.San Francisco, US4623%
31CampfireCampfireYC S23Campfire is the AI-native ERP for high-growth mid-market companies. It automates transaction categorization, bank reconciliation, revenue recognition, and reporting for finance teams.San Francisco, US460%
32Abacus.AIAbacus.AIAbacus.AI is an artificial intelligence research and cloud services company that helps organizations design, train, and operationalize machine and deep learning models. It offers two products: ChatLLM for professionals and small teams and Abacus.AI Enterprise for enterprises and companies. Abacus.AI Enterprise is a generative AI platform that connects to enterprise software systems and automates business processes. The platform serves enterprise customers across sectors such as finance, healthcare, e-commerce, retail, and manufacturing.San Francisco, US4572%
33Thinking Machines LabThinking Machines LabThinking Machines Lab is an artificial intelligence research and product company.San Francisco, US440%
34Apollo.ioApollo.ioApollo.io is a go-to-market solution for revenue teams. It provides sales and marketing teams with access to verified B2B contact data for over 210 million contacts and 35 million companies. The platform includes tools to engage and convert these contacts in one unified platform. Apollo.io also offers an AI Assistant that powers end-to-end agentic workflows across the GTM platform.San Francisco, US4462%
35Cogent SecurityCogent SecurityCogent Security provides an AI-driven platform that automates vulnerability management by continuously ingesting context, prioritizing risks, and coordinating remediation actions with minimal manual effort from security teams. The platform targets various industries, particularly finance and healthcare, and serves a diverse client base including large enterprises.San Francisco, US4357%
36PlaudPlaudPlaud builds wearable and desktop AI devices and software that record, transcribe, and summarize conversations into searchable notes. The AI layer generates summaries that can be role-specific using a library of over 10,000 templates across fields like medical, legal, finance, and education.San Francisco, US420%
37TrueFoundryTrueFoundryTrueFoundry provides an enterprise-grade AI Gateway that encompasses an LLM Gateway, MCP Gateway, and Agent Gateway, enabling enterprises to securely connect, observe, and govern access to models, tools, guardrails, and agents from a single control plane. Beyond the gateway layer, TrueFoundry enables organizations to deploy and train custom LLMs on GPUs, host MCP servers, and run custom agents through a Kubernetes-native interface.San Francisco, US410%
38FieldguideFieldguideFieldguide provides an AI-native platform for audit and advisory firms that automates and streamlines engagement management. The platform offers end-to-end engagement management, insights, analytics, and integration with productivity tools.San Francisco, US4178%
39ServalServalServal is an AI-native automation platform that builds intelligent agents to automate enterprise workflows.San Francisco, US415%
40ConstructorConstructorConstructor provides an AI-powered product discovery and search platform for enterprise ecommerce companies. Its platform uses generative AI and collaborative personalization to deliver search, browse, recommendations, and AI Shopping Agents.San Francisco, US40100%
41AmplitudeAmplitudeYC W12Amplitude is a digital analytics platform that helps companies capture data they can trust, uncover insights about customer behavior, and take faster action. The platform includes AI Agents that sense, analyze, and deliver optimizations to users 24/7. It serves product, data, and marketing teams to build better product experiences that drive business growth.San Francisco, US3946%
42Bedrock Robotics IncBedrock Robotics IncBedrock Robotics develops autonomous systems for heavy construction machinery. The company upgrades customers' existing heavy equipment fleets with reversible hardware and software installs to enable fully autonomous operations.San Francisco, US395%
43CartaCartaCarta is a connected platform and AI-native ecosystem for private capital. It brings together software, services, and legal infrastructure that founders use to manage equity, fund managers use to run administration and reporting, and legal teams use to close transactions. Carta replaces traditional paper-based equity management with a real-time digital cap table that updates automatically as transactions occur.San Francisco, US373%
44WRITERWRITERWRITER provides an enterprise AI agent platform for building and deploying AI agents grounded in company data and powered by its own Palmyra LLMs. The platform includes products like WRITER Agent, Playbooks, AI Studio, and Connectors for IT and business teams.San Francisco, US370%
45Ivo Inc.Ivo Inc.Ivo is an AI-powered contract intelligence platform for in-house legal teams. It operates as a Microsoft Word add-in that applies a company's playbooks clause-by-clause to incoming third-party paper and produces precise redlines.San Francisco, US370%
46FalFalfal is a generative media platform that helps developers create applications using AI models. The platform offers high-performance inference, orchestration, and observability for AI-native products.San Francisco, US3530%
47AeroVectAeroVectAeroVect develops autonomous systems for airport ground support equipment. The company provides the AeroVect Driver, a platform that enables tractors and other vehicles used in cargo and baggage handling to operate without a human driver.San Francisco, US3568%
48BobyardBobyardBobyard is AI takeoff and estimating software built for construction trades. It reads plan sets, measures scope, and helps estimators move from drawings to bids faster.San Francisco, US3517%
49hudhudYC W25Over 50 businesses use HUD to build RL environments, sell them to AI labs, or train their own models from them.San Francisco, US3488%
50ReductoReductoYC W24Reducto is the agentic document platform for leading AI teams who demand enterprise performance at scale. It provides a comprehensive toolkit for working with documents the way a human would, combining custom in-house and leading frontier models to power efficient and accurate document workflows.San Francisco, US335%
51DominoDominoThe platform enables data science, IT, and AI/ML teams to develop, deploy, and manage models within enterprise environments.San Francisco, US33100%
52GigaGigaYC S23Giga builds AI agents that automate customer service and operational workflows across voice, chat, and email. Its platform ingests a company's support knowledge base to generate emotionally intelligent agents that can reason, act, and resolve issues in real time.San Francisco, US3236%
53MossMossYC F25Moss is a real-time semantic search runtime for AI agents, voice agents, copilots, and multimodal apps. It delivers sub-10ms lookups and instant index updates without extra infrastructure.San Francisco, US3113%
54SardineSardineSardine is the leading agentic risk platform for fighting financial crime. Its integrated solution unifies data across risk teams to help organizations stop fraud in real time, prevent AI-driven attacks, and automate fraud and AML operations.San Francisco, US31100%
55InferactInferactInferact builds AI inference infrastructure, primarily through its open-source large language model (LLM) inference engine, vLLM. The company's mission is to grow vLLM as the world's AI inference engine and accelerate AI progress by making inference cheaper and faster. Inferact supports 500+ model architectures and runs on 200+ accelerator types, powering inference at global scale.San Francisco, US3110%
56TalkDeskTalkDeskTalkdesk provides Customer Experience Automation (CXA), a platform that uses autonomous, multi-agent AI orchestration to automate customer service, sales, and support workflows.San Francisco, US2994%
57RoxRoxRox leverages AI agents to enhance sales productivity, providing actionable insights that help close deals.San Francisco, US280%
58FirecrawlFirecrawlYC S22Firecrawl is an API service that converts any URL into clean, LLM-ready markdown or structured data. It provides functionality to crawl entire websites or scrape individual pages, handling dynamic content, JavaScript-rendered pages, proxies, rate limits, and caching behind the scenes.San Francisco, US280%
59Wispr FlowWispr FlowWispr Flow develops a voice dictation app that converts speech to text for writing, messaging, and note taking. Its first product, Flow, lets users talk instead of type anywhere on their computer or phone, and turns messy speech into polished text.San Francisco, US2832%
60Physical IntelligencePhysical IntelligencePhysical Intelligence develops foundation models and learning algorithms to power robots and physically-actuated devices. Its flagship model, π0, is a generalist robot policy model designed to allow robots to learn and perform physical tasks in real-world environments.San Francisco, US280%
61nimble-roboticsnimble-roboticsnimble-robotics’ AI-powered general-purpose robots perform all core warehouse tasks including storage, retrieval, picking, packing, and sorting.San Francisco, US270%
62StradaStradaYC S23Strada is a conversational+agentic AI platform purpose-built for insurance. It deploys expert AI agents across calls, texts, emails, and chat to run core front-office workflows from policy servicing to claims intake.San Francisco, US2759%
63DiscoDiscoDisco develops an AI-driven partnership platform that makes recommendations to consumers across brands.San Francisco, US2786%
64LinearLinearLinear builds a product development system for teams and agents. It provides an issue tracking and project management tool for planning, building, and shipping products.San Francisco, US2789%
65Candid HealthCandid HealthYC W20Candid Health provides an AI-first revenue cycle management platform for healthcare providers. Its platform automates medical billing and claims processing. The company is focused on removing inefficiency and waste from healthcare revenue cycle spending.San Francisco, US2710%
66Listen LabsListen LabsListen Labs’ AI handles study design, participant recruitment, moderation, and analysis across video, voice, and text.San Francisco, US270%
67RoboflowRoboflowYC S20Roboflow offers tools for dataset understanding, automated labeling, model training and finetuning, and deployment to the cloud and edge.San Francisco, US2775%
68ComposioComposioComposio is a developer-focused integration platform that simplifies how AI agents and large language models (LLMs) connect with external applications and services. It provides a consistent way to connect LLMs with real-world tools, third-party APIs, and internal services. Composio offers integrations, workflow automation, and real-time tool observability to help agents operate. The platform handles authentication, triggers, and real-world API actions.San Francisco, US274%
69OmniOmniOmni is an AI analytics platform that turns company data into a trusted source of truth for AI. Teams use Omni to ask questions in plain English, refine answers in workbooks, and bring trusted data into tools like Claude, ChatGPT, Cursor, and Slack.San Francisco, US2754%
70VapiVapiYC W21Vapi is a platform for deploying voice agents that know your business and can listen, adapt, and resolve in minutes. It abstracts away the complexity of building conversational voice agents on top of 3rd party AI models.San Francisco, US270%
71SparklesSparklesYC W26Sparkles is a safe online development environment that lets everyone on your team, not just engineers, take part in shipping software. Agents work on your existing repositories in isolated sandboxes, and every change comes back as a pull request.San Francisco, US2719%
72Assort HealthAssort HealthAssort Health builds an AI voice agent for healthcare that handles the entire patient journey, from referrals and scheduling to intake and follow-up.San Francisco, US260%
73Prime IntellectPrime IntellectPrime Intellect’s platform, Lab, unifies compute, environments, evaluations, secure sandboxes, high-performance training, and deployment into one system for post-training at frontier scale.San Francisco, US2645%
74Nightfall AINightfall AINightfall AI provides an AI-native data loss prevention and insider risk management platform that protects sensitive data across SaaS apps, GenAI tools, email, and endpoint devices.San Francisco, US2627%
75NumeralNumeralYC W23Numeral is an AI-native indirect tax solution for U.S. and global businesses. It automates sales tax compliance for ecommerce and SaaS businesses, handling registration, monitoring for tax liabilities, rate calculation, collection, exemption certificate management, and filing and remittance of returns.San Francisco, US2635%
76BraintrustBraintrustBraintrust is the agent observability platform. By actively applying intelligence to agent traces and automatically surfacing the most critical patterns, Braintrust gives teams the visibility to understand how agents behave in production and the tools to improve them.San Francisco, US2630%
77OpenArt AIOpenArt AIOpenArt is an all-in-one platform for creating AI images and videos. Users can generate images through over 100 fine-tuned AI models without requiring technical expertise.San Francisco, US2528%
78Brain Co.Brain Co.Brain Co. builds AI-native operating systems for large, regulated institutions. Each system is built for a specific industry, powered by agents that push real workflows forward. Underneath it all is Atlas, a proprietary platform that keeps customers in control, secure by design, and never locked into one model.San Francisco, US259%
79CartesiaCartesiaCartesia provides real-time multimodal intelligence for all devices. The company builds its models on State Space Models (SSMs), a new primitive for low latency, long-context reasoning, and greater efficiency at scale.San Francisco, US250%
80SpeakSpeakYC W17Speak is building an AI-powered language tutor that lets learners speak out loud and get instant feedback.San Francisco, US258%
81SigmoidSigmoidSigmoid is an AI-first company that helps organizations modernize data, transform business processes, and make better decisions using data and AI. Enterprises partner with Sigmoid to build bespoke GenAI and Agentic AI solutions powered by strong data foundations and contextual knowledge.San Francisco, US25—
82SesameSesameSesame is designing a new kind of computer focused on making voice agents part of daily life.San Francisco, US250%
83Edison ScientificEdison ScientificEdison Scientific builds and deploys AI scientist agents to accelerate science and the development of new medicines.San Francisco, US2422%
84interface.aiinterface.aiinterface.ai’s AI platform delivers a unified experience across voice, digital, and employee-assisted channels. The platform is pre-trained in over 60 banking-specific use cases and powers over 70 financial institutions.San Francisco, US234%
85Broccoli AIBroccoli AIYC W22Broccoli builds AI agents that answer phones, book appointments, follow up with customers, and recover revenue for plumbing, HVAC, and electrical contractors.San Francisco, US2313%
86JuiceboxJuiceboxYC S22Juicebox is an AI-native recruiting platform used by over 5,000 companies worldwide to find and engage top talent faster with AI-powered search, outreach sequencing, and autonomous agents. The platform features AI agents that source profiles from various data and run automated, personalized outreach sequences.San Francisco, US230%
87Dev Tools AIDev Tools AIDev Tools AI assist in the rapid development of web and mobile app tests. It offers an AI-powered automation service that uses AI to automate testing of web and mobile applications without requiring access to page source code.San Francisco, US239%
88AfterQueryAfterQueryYC W25The company works with nearly 100,000 domain experts to create training data for AI labs and enterprises.San Francisco, US234%
89NumericNumericNumeric is an AI accounting automation platform that unifies close management, reporting, and cash for complex accounting teams. It centralizes transaction data from ERPs, bank feeds, and CSVs to enable real-time visibility into financial operations.San Francisco, US230%
90ImagineArtImagineArtImagineArt is an AI-powered creative suite that transforms text prompts into high-quality images, videos, and music.San Francisco, US2330%
91HarperHarperYC W25Harper is an AI-native commercial insurance brokerage that uses a digital platform to help businesses assess risk exposure and secure appropriate coverage. Its platform automates risk assessment, matches clients with optimal insurance products, and streamlines application and renewal processes.San Francisco, US225%
92NeticNeticNetic’s AI agents autonomously handle inbound customer interactions across calls, text, web chat, and third-party platforms, booking jobs directly into CRM or field service management systems.San Francisco, US220%
93OrchestraOrchestraOrchestra is the agentic operations platform for drug development. It helps R&D organizations unify planning, automate operations, and reduce risks.San Francisco, US2214%
94Foundation RoboticsFoundation RoboticsFoundation Robotics builds Phantom humanoid robots with autonomous AI and hardware for businesses in consumer goods, beverage, and glass manufacturing.San Francisco, US22—
95HerculesHerculesHercules has all the features and integrations you need to build and deploy powerful apps. > Hercules makes it easy to build stunning apps and websites by chatting with AI.san francisco, US22100%
96LevelpathLevelpathLevelpath is an AI-native procurement platform for global enterprises. Levelpath's AI Agents autonomously handle tasks such as sourcing event creation, supplier onboarding, and risk assessments.San Francisco, US215%
97FundamentalFundamentalFundamental has built NEXUS, a Large Tabular Model (LTM) purpose-built for structured enterprise data. NEXUS generates high-accuracy, explainable predictions from large-scale structured tabular data.San Francisco, US2163%
98Artemis SearchArtemis SearchArtemis Search develops AI-based sales prospecting software for B2B lead generation.San Francisco, US2148%
99StackAIStackAIStackAI is a no-code AI workflow platform that enables companies to build, deploy, and scale AI-powered workflows. Its drag-and-drop interface allows teams to automate tasks such as data extraction, content generation, and compliance reviews.San Francisco, US2124%
100GammaGammaGamma is an AI-powered platform that creates working presentations, documents, and visual content.San Francisco, US210%

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Frequently asked

What is an AI-native company?

An AI-native company is built around AI models from its first product: the model is the product or its core, not a feature added later. Companies here are classified from their own product descriptions and hiring, and ranked by how many roles they have open now.

Which AI-native companies in San Francisco are hiring the most?

Right now: Databricks, OpenAI, Anthropic, Clera, Harvey. The table above ranks every company in the list by roles open today.

Do AI-native companies in San Francisco hire remotely?

21% of the companies listed have most of their open roles remote. Each company page shows its exact remote share.

Can Enzo apply to these companies for me?

Yes. Enzo applies on each company’s own site with your profile and writes the answers for every role. You get 25 free auto-applies, no card.

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