Company list · updated daily

AI-native companies in Boston hiring (2026)

The AI-native companies in Boston hiring the most right now are Motional, Cohere Health and 7AI. 39% of the companies listed here have most of their open roles remote. Open roles are read daily from each company’s own careers page.

An AI-native company is built around AI models from its first product: the model is the product or its core, not a feature added later. Companies here are classified from their own product descriptions and hiring, and ranked by how many roles they have open now.

#CompanyHeadquartersOpen rolesRemote
1MotionalMotionalMotional develops and deploys SAE Level 4 autonomous vehicles for driverless ride-hail and delivery services.Boston, US7474%
2Cohere HealthCohere HealthCohere Health’s clinical intelligence platform and agentic AI-powered solutions connect health plans’ strategic goals and providers’ needs, optimizing the speed, cost, and quality of care. The company processes more than 12 million prior authorization requests annually for more than 600,000 providers nationwide.Boston, US47100%
37AI7AI7AI’s agents handle alert triage, threat investigation, and incident response, reducing manual workload for security teams.Boston, US3855%
4BlitzyBlitzyBlitzy orchestrates thousands of specialized agents to plan, build, and validate code at scale.Boston, US3339%
5Venti TechnologiesVenti TechnologiesVenti Technologies develops and deploys AI-powered autonomous vehicle logistics solutions for ports, airports, warehouses, and factories.Boston, US300%
6Code MetalCode MetalCode Metal provides an AI-enabled platform for verifiable code translation and optimization, converting high-level code into production-ready formats for deployment across varied hardware targets. Its platform accelerates deployment of DSP, RF, communications, and embedded signal processing algorithms onto heterogeneous compute targets including GPUs, FPGAs, ASICs, and edge SoCs.Boston, US2993%
7Air Space IntelligenceAir Space IntelligenceAir Space Intelligence (ASI) is a dual-use software company that deploys predictive AI to complex operating environments. Its first product, Flyways AI, is an AI-powered air operations platform for airspace surveillance, flight monitoring and optimization.Boston, US2615%
8Neo SecurityNeo SecurityNeo Security prevents agentic threats across devices, browsers, identities, and applications used in AI-driven enterprises.Boston, US2123%
9Merlin LabsMerlin LabsMerlin Labs builds autonomous aviation systems for civil and defense customers, and the engineering organization behind that work needs a leader who is personally expert in civil certification and who can manage the work of the military airworthiness lead and Cyber Certification Lead.Boston, US1942%
10OverjetOverjetOverjet is the world-leader in dental AI. Its FDA-cleared technology analyzes dental X-ray images using AI to detect oral diseases and visualize oral health.Boston, US1861%
11DataRobotDataRobotDataRobot delivers an end-to-end agentic platform for production-grade AI. The platform supports predictive, generative, and agentic artificial intelligence, along with governance and observability features.Boston, US16100%
12Zone & CoZone & CoZone & Co provides an ERP-native AI platform for financial operations built for organizations running on Oracle NetSuite. Its platform spans Quote-to-Cash, Procure-to-Pay, Treasury, Payroll Management, and Record-to-Report. Zone & Co serves more than 4,500 customers worldwide.Boston, US16100%
13Maven AGIMaven AGIMaven AGI is an enterprise AI agent platform that automates customer support across chat, email, voice, and web, resolving up to 93% of incoming queries without human intervention.Boston, US1638%
14VideaHealthVideaHealthVideaHealth provides AI-powered software that automatically detects pathologies in dental imaging, helping dentists avoid missing diseases. The company also offers AI-generated workflow tools and revenue cycle management for the dental industry.Boston, US1346%
15BoltzBoltzBoltz builds AI-powered molecular modeling tools to make biology programmable and accelerate drug discovery. The company delivers these capabilities through Boltz Lab, a platform for running its models and design agents as production-grade tools.Boston, US1392%
16PathAIPathAIPathAI is a provider of AI-powered research tools and services for pathology. Its core product is AISight, a cloud-native intelligent enterprise workflow solution for end-to-end digital pathology.Boston, US1242%
17Tristar AITristar AITristar AI is hiring a Sales Operations & Marketing Manager to help scale our go-to-market efforts as we bring AI-powered computer vision solutions to manufacturers across North America. Tristar AI provides manufacturers with the world's most advanced computer vision AI system that keeps track of when things go wrong in production, quality, and maintenance.Boston, US100%
18MendMendMend.io is the security platform built for every risk, across application security and AI security — securing the code layer, the AI layer, and the attack surface between them. Mend.io offers the first AI native application security platform, empowering organizations to build and run a proactive AppSec program tuned for AI powered development.Boston, US1070%
19AcuityMDAcuityMDAcuityMD is an AI platform for MedTech that helps commercial teams identify target markets, surface top opportunities, and grow their business.Boston, US9100%
20Terra SecurityTerra SecurityTerra Security provides an agentic AI-powered continuous penetration testing platform. The platform unifies continuous agentic pentesting across AI systems, network infrastructure, and web apps with a human-on-the-loop for safety and compliance.Boston, US944%
21Counsel HealthCounsel HealthCounsel Health delivers AI-enabled, physician-supervised primary care through a secure messaging-based experience.Boston, US825%
22Mira MaceMira MaceMira Mace pairs Medicare beneficiaries with a dedicated healthcare advocate who navigates appointments, insurance, and care coordination on their behalf.Boston, US863%
23PhaseVPhaseVPhaseV offers AI-driven solutions that enhance clinical development for biopharma sponsors and contract research organizations (CROs). PhaseV provides AI-driven solutions for efficient clinical development and operations.Boston, US7—
24Ampliwork, IncAmpliwork, IncAmpliwork builds enterprise-grade AI agents that automate complex multi-step workflows. Its AI agents are designed for highly regulated industries such as Financial Services.Boston, US667%
25Manifold BioManifold BioManifold Bio is a platform therapeutics company building the first AI-guided direct-to-vivo discovery platform.Boston, US50%
26NebulockNebulockNebulock is an agentic threat hunting platform that autonomously surfaces behaviors, not just IOCs, from various data sources.Boston, US4100%
27FairmarkitFairmarkitFairmarkit provides an autonomous sourcing platform that uses AI and GenAI to automate procurement workflows.Boston, US475%
28Blue Water AutonomyBlue Water AutonomyBlue Water Autonomy is building autonomous ships designed for endurance and scalable production to operate across the open ocean. Its autonomous ship design fully-integrates hardware, software, and AI allowing the vessel to operate on the open ocean for months at a time. The company positions itself within the defense technology sector, aiming to modernize naval power and U.S. shipbuilding through autonomous warship designs.Boston, US4—
29mablmablmabl Inc. is an innovative provider of AI-powered test automation solutions that streamline the software development lifecycle, enabling users to enhance testing efficiency and quality with low-code capabilities. mabl offers an AI-powered test automation platform that integrates seamlessly into the software development lifecycle.Boston, US30%
30Absentia LabsAbsentia LabsAbsentia Labs builds AI foundation models that predict how medicines behave inside the human body. The company develops AI systems that learn from biological, chemical, and clinical data to model drug behavior, predict safety and efficacy, and accelerate decision-making across the development pipeline.Boston, US333%
31OnCorps AIOnCorps AIOnCorps AI delivers intelligent exception resolution for fund operations, primarily serving asset managers and fund administrators. The company offers AI-based reconciliation tools that automate data matching, review, and investigation, and AI-driven review solutions for financial reporting.Boston, US367%
32CodaMetrixCodaMetrixCodaMetrix provides an AI-powered autonomous medical coding platform that translates clinical documentation into accurate billing codes across multiple specialties.Boston, US2—
33Catena LabsCatena LabsCatena Labs is building an AI-native financial institution: regulated infrastructure for AI agents and their human collaborators with stablecoins as a native settlement rail.Boston, US2—
34Nextera Robotics | DIDGE.aiNextera Robotics | DIDGE.aiYC S20Nextera Robotics | DIDGE.ai provides site digitization software for construction teams, combining progress tracking, safety monitoring, quality control, and billing.Boston, US2—
35Publicis SapientPublicis SapientPublicis Sapient provides enterprise AI platforms and services. Its AI platforms, Sapient Bodhi, Sapient Slingshot and Sapient Sustain, help organizations reinvent how they build, operate and deliver by pairing human ingenuity with agentic systems.Boston, US1—
36PoshPoshPosh has most recently launched a [Knowledge Assistant](https://www.posh.ai/knowledge-assistant) to help their customers’ employees get faster, easier access to internal informationBoston, US1—
37PostEraPostEraPostEra uses Proton, its AI platform for medicinal chemistry, to accelerate the discovery of new medicines for patients.Boston, US1—
38Cellular IntelligenceCellular IntelligenceCellular Intelligence is an AI-native TechBio company building a universal foundation model of cell signaling to understand, predict, and control cellular behavior. The company generates dynamic cellular data at over 1,000x higher efficiency than conventional methods and trains large-scale predictive models to design regenerative medicine protocols, predict drug responses, and model disease mechanisms.Boston, US1—

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Frequently asked

What is an AI-native company?

An AI-native company is built around AI models from its first product: the model is the product or its core, not a feature added later. Companies here are classified from their own product descriptions and hiring, and ranked by how many roles they have open now.

Which AI-native companies in Boston are hiring the most?

Right now: Motional, Cohere Health, 7AI, Blitzy, Venti Technologies. The table above ranks every company in the list by roles open today.

Do AI-native companies in Boston hire remotely?

39% of the companies listed have most of their open roles remote. Each company page shows its exact remote share.

Can Enzo apply to these companies for me?

Yes. Enzo applies on each company’s own site with your profile and writes the answers for every role. You get 25 free auto-applies, no card.

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